The race is on to find a way of predicting the onset of the

Predicting Alzheimer’s

canada goose outlet locations in toronto Graham Intro: Alzheimer’s Disease canada goose coats is the main cause of Dementia and cripples around 200,000 Australians and its only set to get worse due to uk canada goose our ageing population. The race is on to find a way of predicting the onset of the disease which costs the economy between $6 and $7billion a year. Early diagnosis will not only relieve our health burden, it will allow people to make lifestyle choices which could delay the onset of the disease. Now, a new brain imaging technique may be able to do just that predict a diagnosis years before the disease damages the brain. Maryanne Demasi investigates. canada goose outlet locations in toronto

canada goose outlet in montreal Robert Holland: Susan drove off one Canada Goose Parka day to go to an appointment and she was due home canada goose black friday sale in about 2hrs. I guess after about half an hour I was a little concerned and another half an hour I was really concerned. I was quite distressed. It was something canadian goose jacket totally out of my control. After some time the phone rang. She’d driven way past where she was supposed to be. She had no idea how she Canada Goose Online could get back home. She was distressed buy canada goose jacket cheap beyond belief because she’d both missed the appointment and also began to realise that it was going to be very, very difficult to go out on her own. canada goose outlet in montreal

canada goose outlet store uk Dr Maryanne Demasi: Getting lost on canada goose a familiar canada goose factory sale road was the final crunch for Susan. She’d been losing her memory for many years but it was at this point she decided to give up her driver’s license and worst of all, her independence. canada goose outlet store uk

canada goose outlet toronto factory Robert: It was love at first sight, without any Canada Goose Coats On Sale question. We’d both been in relationships before, but I hadn’t met anyone like Susan. canada goose outlet toronto factory

canada goose parka uk Susan Holland: I just was in raptures canada goose parka uk

canada goose outlet us Robert: I proposed 3 days after we met and we’ve now been married for over 38 years. canada goose outlet us

canada goose discount uk Narration: But in a devastating blow, Susan was diagnosed with Alzheimer’s Disease several years ago. canada goose discount uk

canada goose outlet real Robert and Susan: You’ve got to continue to live as though there’s nothing wrong, but there is something wrong you’ve just got to accept that fact. canada goose outlet real

canada goose outlet uk Narration: A distinguished career as a nurse and midwife was taken from her. Although she still remembers the details of the day she met Robert, her recall for the simplest things has diminished. canada goose outlet uk

canada goose outlet winnipeg Robert: Do you know how old you are now? canada goose outlet winnipeg

canada goose outlet canada Susan: Probably not canada goose outlet canada

canada goose outlet paypal Robert: Ah, buy canada goose jacket that’s not important. canada goose outlet paypal

canada goose uk site Narration: Alzheimer’s looms like an ominous fog. It gradually takes your brain hostage eroding everything that makes you human, your personality, your memory and eventually your ability to think and speak. It’s heartbreaking to know Robert is gradually losing his best friend. But it’s their wedding vows he remembers when things get tough. canada goose uk site

canada goose jacket outlet uk Robert and Susan: That’s where it started. For richer or poorer, for better, for worse, in sickness and in health and that’s what the cheap canada goose uk words really mean. canada goose jacket outlet uk

canada goose outlet toronto address Professor David Ames: In the world, there are about 27 million people with dementia at the moment. By 2040 we think there will be about 81 million, so it’s a significant public health challenge. canada goose outlet toronto address

canada goose outlet vip The process of Alzheimer’s disease probably starts 10 to 20 years before people show symptoms of memory impairment. If we canada goose coats on sale could pick Canada Goose online up the fact that somebody’s getting Alzheimer’s disease, at an early canada goose uk shop stage we could intervene and treat before they ever have symptoms and then they wouldn’t get disability. canada goose outlet vip

canada goose outlet toronto Narration: The Alzheimer’s brain becomes riddled with toxic deposits of a protein called beta amyloid. These deposits disrupt the chemical signals between nerve cells and damage their connections. Ultimately, the beta amyloid destroys the nerve cells and the brain shrinks and the damage is canadagooseoutlete largely irreversible. canada goose outlet toronto

canada goose outlet belgium Maryanne: Until now, an autopsy in a morgue like this was the only way you could visualise the amyloid build up in the brain canada goose store But of canada goose uk black friday course too late for the patient. Now, there’s a way of detecting the build up, early, while the patient is still alive. canada goose outlet belgium

canada goose outlet in chicago Professor Christopher Rowe: There are canada goose outlet difficulties in the current diagnosis of Alzheimer’s disease. It’s not terribly accurate compared uk canada goose outlet to what’s found at post mortem, and it’s made late in the course of the disease. canada goose outlet in chicago

canada goose outlet price Narration: This PET scanner is putting scientists at the forefront of Alzheimer’s detection. Now, there’s nothing new about PET scanners, but what is new is the dyes they’re using to detect the beta amyloid in the brain scans. The dyes contain a highly unstable radio isotype so they have to be made on site, immediately prior to use. canada goose outlet price

canada goose outlet uk sale Maryanne: This machine, called a cyclotron, actually makes the radioisotopes and it’s surrounded by a 2m thick concrete bunker if I was to stay in here while the machine was on I’d Canada Goose Outlet be toast. The radioisotopes are then brought to this chemistry lab and attached to a special chemical which binds to the amyloid in the brain and lights up canada goose clearance sale bright yellow or bright red on the scan. canada goose outlet uk sale

canada goose outlet jackets Professor Rowe: On the left side we have a normal scan. On this side we have the typical findings in a patient with Alzheimer’s canada goose clearance disease. You can see all the bright yellow and red areas. That’s where the radioactive tracer has stuck to the amyloid in the brain in what’s called the grey matter. canada goose outlet jackets

canada goose outlet england Maryanne: So this is typically what Susan’s brain would look like? canada goose outlet england

canada goose outlet vancouver Professor Rowe: Yes, Canada Goose sale that’s very typical of the scan that we got from cheap Canada Goose Susan. canada goose outlet vancouver

canada goose factory outlet toronto location Narration: The CSIRO’s Preventative Health Flagship initiated a 3 year trial involving over 1000 volunteers, including Susan and the results are astonishing. canada goose factory outlet toronto location

canada goose outlet winnipeg address Professor Rowe: The big finding is that we’re finding amyloid in of Canada Goose Jackets the brains of 25% of apparently normal people aged over 65. canada goose outlet winnipeg address

canada goose outlet near me Robert Holland: It removes that whole area of uncertainty. Once you’ve got that diagnosis you can then focus on that area and deal with it in a certain way. canada goose outlet near me

canada goose outlet nyc Maryanne: Of course these scans don’t come canada goose uk outlet cheap. They cost around a thousand dollars a pop. And there’s only two sites in Australia that do them, here in Melbourne and the other in Perth; So its not really feasible to screen a whole population. canada goose outlet nyc

canada goose stockists uk Narration: That’s why Prof Ralph Martins is developing a fast, simple and cheap way of detecting beta amyloid using a blood test canada goose stockists uk.

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